Prevalência de infecção tuberculosa latente conforme as macrorregiões de saúde de Santa Catarina, Brasil/ Prevalence of latent tuberculosis infection by health macro-Regions of Santa Catarina, Brazil/ Prevalencia de infección tuberculosa latente según las macrorregiones de salud de Santa Catarina, Brasil

Authors

  • Emanuela Emanuela Federal University of Santa Catarina/Pediatrics Department
  • Emil Kupek Federal University of Santa Catarina/ Department of Public Health

DOI:

https://doi.org/10.30681/2526101014109

Keywords:

Tuberculosis; Interferon-gamma Release Tests; Vulnerable Populations; Epidemiology; Social Determinants of Health

Abstract

Objective: to evaluate the prevalence of Latent Tuberculosis Infection (LTBI), according to IGRA-positive testing, across the seven health macro-regions of Santa Catarina.  Method: an observational, analytical, cross-sectional study using secondary data from the Notifiable Diseases Information System (SINAN), the state system VIGILANTOS, and the database of the Central Public Health Laboratory of Santa Catarina (LACEN/SC), registered in 2023, evaluating incidence and prevalence.  Results: the incidence of tuberculosis in all forms was higher than the state average in three macro-regions, in descending order: Foz do Rio Itajaí, Greater Florianópolis, Meio Oeste/Serra Catarinense, and South. In all regions, there was greater involvement among individuals aged 15 to 49 years, with a prevalence of 31.44/100,000 inhabitants. The highest prevalences of IGRA-positive results were observed in the South macro-region (12.8/million) and Greater Florianópolis (8.10/million). The Foz do Rio Itajaí macro-region, fifth in population size, presented an incidence coefficient above the national and state averages (51.9/100,000), followed by Greater Florianópolis (42.0/100,000), standing out among people deprived of liberty and people living with HIV.  Conclusion: the high prevalence of IGRA-positive results in the South and Greater Florianópolis macro-regions demonstrates that the use of this new diagnostic method for LTBI may favor preventive treatment and prevent future illness.

Author Biographies

  • Emanuela Emanuela, Federal University of Santa Catarina/Pediatrics Department

     

    Professor in the Department of Pediatrics at the Federal University of Santa Catarina.

    PhD student in the Graduate Program in Medical Sciences at UFSC.

    Pediatric Infectious Disease Specialist.

  • Emil Kupek, Federal University of Santa Catarina/ Department of Public Health

    Department of Public Health, Full Professor.

    Professor of the Graduate Program in Medical Sciences at the Federal University of Santa Catarina.

References

1. World Health Organization. Global tuberculosis report 2024. Geneva: World Health Organization; 2024.

2. Boletim Epidemiológico. Tuberculose. Departamento de HIV/Aids, Tuberculose, Hepatites Virais e Infecções Sexualmente Transmissíveis. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde; 2025.

3. World Health Organization. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents. World Health Organization; 2022 Mar 21.

4. Holtgrewe LM, Johnson A, Nyhan K, Boffa J, Shenoi SV, Karat AS, et al. Burden of tuberculosis in underserved populations in South Africa: a systematic review and meta-analysis. PLOS Glob Public Health. 2024; 4(10):e0003753.

5. Lin HH, Ezzati M, Murray M. Tobacco smoke, indoor air pollution and tuberculosis: a systematic review and meta-analysis. PLoS medicine. 2007; 4(1):e20.

6. Jackson C, Southern J, Lalvani A, Drobniewski F, Griffiths CJ, Lipman M, et al. Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax. 2019; 74(1):91-4.

7. Cruz VD, Harter J, Oliveira MM, Gonzales RI, Alves PF. Consumo de crack e a tuberculose: uma revisão integrativa. SMAD Rev Eletrônica Saúde Mental Álcool Drog. 2013; 9(1):48-55.

8. Nogueira PA, Abrahão RM, Galesi VM. Tuberculosis and latent tuberculosis in prison inmates. Rev saude publica. 2012; 46:119-27.

9. Pavinati G, Lima LV, Radovanovic CA, Magnabosco GT. Geoprogrammatic disparities in the performance of tuberculosis indicators in the homeless population in Brazil: an ecological approach. Rev Bras Epidemiol. 2023; 26:e230048.

10. Ghosh S, Dronavalli M, Raman S. Tuberculosis infection in under‐2‐year‐old refugees: Should we be screening? A systematic review and meta‐regression analysis. J Paediatr Child Health. 2020; 56(4):622.

11. Nolt D, Starke JR. Committee on Infectious Diseases. Tuberculosis infection in children and adolescents: testing and treatment. Pediatrics. 2021; 148(6).

12. World Health Organization. WHO operational handbook on tuberculosis. Module 1: prevention-tuberculosis preventive treatment. World Health Organization; 2024.

13. Ministério da Saúde (BR). Nota Informativa nº 2/2022-CGLAB/DAEVS/SVS/MS: orientações sobre [Recomendações para a utilização do teste de liberação de interferon-gama (IFN-γ)]. Brasília (DF): Ministério da Saúde; 2022.

14. Deliberação 195/CIB/2018. Comissão Intergestores Bipartite de Santa Catarina. Dispõe sobre diretrizes e definições no âmbito da saúde pública do estado de Santa Catarina. Santa Catarina; 2018.

15. Instituto Brasileiro de Geografia e Estatística (IBGE). Ceso demográfico 2022. Rio de Janeiro: IBGE; 2022.

16. Sistema de Informação de Agravos de Notificação (SINAN). Secretaria do Estado da Saúde de Santa Catarina. Superintendência de Vigilância em Saúde. Diretoria de Vigilância Epidemiológica. [Internet]. Florianópolis: Secretaria do Estado da Saúde de Santa Catarina; 2024. Acesso em 11/07/2024.

17. Stata Corp. Stata Statistical Software: Release 18. College Station, TX: StataCorp LLC; 2023.

18. Nogueira PA, Abrahão RM, Galesi VM. Tuberculosis and latent tuberculosis in prison inmates. Rev Saude Publica. 2012; 46:119-27.

19. Sonnenberg P, Glynn JR, Fielding K, Murray J, Godfrey-Faussett P, Shearer S. How soon after infection with HIV does the risk of tuberculosis start to increase? A retrospective cohort study in South African gold miners. J Infect Dis. 2005;191(2):150-8.

20. Bueno JGL, Navarini IGF, Carvalho ER. Tuberculose de sistema nervoso central em crianças e adolescentes: um estudo descritivo em um hospital referência do sul do Brasil. Rev Saúde Pública Paraná. 2024; 7(2):1-5.

21. Thwaites GE, van Toorn R, Schoeman J. Tuberculous meningitis: more questions, still too few answers. The Lancet Neurology. 2013; 12(10):999-1010.

22. Navarini IGF, Bueno JGL, Carvalho ER. Tuberculose extrapulmonar em crianças e adolescentes em hospital referência de Florianópolis-SC. J Health NPEPS. 2024; 9(2):e12992.

Published

2026-06-01

Issue

Section

Artigo Original/ Original Article/ Artículo Originale

How to Cite

Emanuela, E., & Kupek, E. (2026). Prevalência de infecção tuberculosa latente conforme as macrorregiões de saúde de Santa Catarina, Brasil/ Prevalence of latent tuberculosis infection by health macro-Regions of Santa Catarina, Brazil/ Prevalencia de infección tuberculosa latente según las macrorregiones de salud de Santa Catarina, Brasil. Journal Health NPEPS, 11(1). https://doi.org/10.30681/2526101014109