INFECÇÃO SANGUÍNEA POR CANDIDA EM PACIENTES COM NEOPLASIA HEMATOLÓGICA: TAXONOMIA POLIFÁSICA E SUSCETIBILIDADE ANTIFÚNGICA
Resumo
As infecções de corrente sanguínea por espécies de Candida têm sido identificadas como importantes causas de óbitos em pacientes com neutropenia submetidos à quimioterapia para tratamento de neoplasias hematológicas. Este estudo teve como objetivo verificar a ocorrência destas infecções em pacientes internados no serviço de hematologia e oncologia de um hospital público especializado no tratamento de câncer no Nordeste do Brasil. Um total de 105 amostras clínicas de 62 pacientes com neoplasias hematológicas foram analisadas no Laboratório de Micologia Médica da Universidade Federal de Pernambuco. Apenas 7 indivíduos estavam no ambiente de UTI. O diagnóstico micológico foi realizado por meio de automação (BACTEC 9120 / PHOENIX ™), identificação proteômica (MALDI-TOF MS) e análise molecular (PCR). O teste de susceptibilidade antifúngica seguiu as recomendações do Clinical & Laboratory Standards Institute. Dentre as amostras estudadas, nove cepas (8,57%) eram do gênero Candida, sendo seis C. tropicalis e três C. albicans. Os isolados foram completamente sensíveis aos antifúngicos testados. Óbitos ocorreram em 66,6% dos casos. Pacientes com neoplasias hematológicas internados em terapia intensiva e em estado de choque séptico apresentam maior risco de ocorrência de infecções de corrente sanguínea e óbito por espécies de Candida.
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