Clinical evaluation of the anti-inflammatory effect of baccharis dracunculifolia propolis gel on cervicitis

Autores

  • Niraldo Paulino
  • José Reinaldo Coutinho
  • Lucas Amorim Coutinho
  • Amarilis Scremin

Resumo

Propolis is a natural product produced by bees and used widely to treat inflammatory and infectious diseases. Cervicitis is an inflammation of the uterine cervix, normally caused by sexually transmitted infections or by non-infectious causes, such as contraceptive diaphragms, allergy to latex condoms or intrauterine devices. We have developed a propolis formulation patented in Brazil PI0904121-4A2 on 01/09/2006. The objective of this work is to evaluate the anti-inflammatory effect of standardized Brazilian propolis (G1) gel on cervicitis. Twenty eligible women with recurrent cervicitis were randomly assigned to the treatment of our study. This study was performed on the group with cervicitis as evaluated by neutrophil analysis of cervico-vaginal material before and after treatment with G1 during 7 or 14 days. These women received G1 and were instructed to use it for the next seven days. We demonstrated that treatment for seven days resulted in a significant decrease in the number of neutrophils in the collected cervico-vaginal material. After seven and fourteen days, respectively, the level of inhibition in the vulva was 55±5% for both, 38±4% and 60±5% in the vagina, and 39±4% and 37±5% in the cul-de-sac. In the colon (data after seven days), the inhibition was 55±6%, and, in contrast, inhibition in the endocervix was 49±5%. The results follow the same pattern as our recent results showing that the anti-inflammatory effect of propolis may be due to the inhibition of iNOS gene expression, through interference in NF-?B sites in the iNOS promoter in association with decrease of prostaglandin E2 production. These results suggest that G1 may be an important new bioproduct to use during chronic cervicitis.

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Publicado

2015-02-16

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Clinical evaluation of the anti-inflammatory effect of baccharis dracunculifolia propolis gel on cervicitis. (2015). Revista Ciência E Estudos Acadêmicos De Medicina, 1(02). https://periodicos.unemat.br/index.php/revistamedicina/article/view/355