Histological analysis of rat prostate under exogenous testosterone and low dose of oral selenium administration/ Histología de la próstata de ratón influenciada por testosterona y la dosis supra-nutricional de selenio/ Histologia da próstata de rato...


  • Sergio Marcelino de Oliveira Universidade Federal de Mato Grosso, Campus Universitário do Araguaia UFMT-CUA
  • Loiane dos Santos Silva Rio Preto University Center - UNIRP, S.J. Rio Preto, SP-Brazil
  • Rafaela Heloise Cardoso Ledesma Rio Preto University Center - UNIRP, S.J. Rio Preto, SP-Brazil
  • Rodolpho Gonçalves da Silva Rio Preto University Center - UNIRP, S.J. Rio Preto, SP-Brazil


Prostate, Testosterone, Selenium compounds


Objective: to verify selenium effectiveness in maintenance of prostate tissue architecture. Method: experimental study using 20 adult male rats, 90 days old, were divided in followed groups: TG, 05 animals that received testosterone administration; TSG, 05 animals that received testosterone administration and doses of selenium by gavage; CG1, 05 intact animals; CG2, 05 animals that received saline injection, and saline by gavage. Results: characteristic architecture was found in tissue samples from animals of CG with cubic/prismatic secretory epithelium surrounded by fibro-muscular stroma. Animals of TG showed an increase in prostatic epithelium height, increase in the number of blood vessels in stroma and presence of proliferative lesions. Proliferative lesions were also found in tissue samples from animals of TSG, besides having improve in epithelial height, as seen in TG. Conclusion: it is concluded that selenium at this concentration has no effectiveness in modulating morphology of prostatic tissue of adult rats.


Price D. Comprative aspects of development and structure in the prostate. Nat Can Inst Monogr. 1963; 12:1-27.

Brandes D. The fine structure and histochemistry of prostatic glands in relation to sex hormones. Int Rev Cytol. 1966; 20:207-76.

Srougi M, Ribeiro LA, Piovesan AC, Colombo JR, Nesrallah A. Prostate Diseases. Rev Med. 2008; 87(3):166-77.

Filho GB, Pereira FEL, Pitella JEH, Bambirra EA, Barbosa AJA. Bogliolo: Patologia Geral. Rio de Janeiro (RJ): Guanabara Koogan; 1993.

Roosen A, Gratzke C, Herrlemann A, Magistro G, Strittmatter F, Weinhold P, et al. Etiology and pathophysiology of benign prostate hyperplasia. Urologe A. 2013; 52(2):186-92.

Banerjee PP, Banerjee S, Brown TR, Zirkin BR. Androgen action in prostate function and disease. Am J Clin Exp Urol. 2018; 6(2):62-77.

Oliveira SM, Vilamaior PSL, Corradi SL, Goes RM, Taboga SR. Cellular and extracellular behavior in the gerbil (Meriones unguiculatus) ventral prostate following different types of castration and the consequences of testosterone replacement. Cell biol int. 2007; 31(3):235-45.

Corradi LS, Goes RM, Carvalho HF, Taboga SR. Inhibition of 5-alpha-reductase activity induces stromal remodeling and smooth muscle dedifferentiation in adult gerbil ventral prostate. Differentiation. 2004; 72(5):198-208.

Liu M, Yao W, Zhu Y, Liu H, Zhang J, Jia L. Characterization, antioxidant and antiinflammation of mycelia selenium polysaccharides from Hypsizygus marmoreus SK-03. Carbohydr Polym. 2018; 201:566-74.

Kryscio RJ, Abner EL, Caban-Holt A, Lovell M, Goodman P, Darke AK, et al. Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial. JAMA Neurol. 2017; 74(5):567-73.

Ferguson LR, Philpott M, Karunasinghe N. Dietary cancer and prevention using antimutagens. Toxicology. 2000; 197(1-3):147-59.

Thompson HJ. Selenium as an anticarcinogen. J. Agric. Food Chem. 1984; 32(3):422-5.

Petrie HT, Klassen LW, Klassen PS, O'Dell JR, Kay HD. Selenium and the immune response: 2. Enhancement of murine cytotoxic T-lymphocyte and natural killer cell cytotoxic in vivo. J Leukoc Biol. 1989; 45(3):215-20.

Peters KM, Carlson BA, Gladyshev VN, Tsuji PA. Selenoproteins in colon cancer. Free Radic Biol Med. In press 2018. https://doi.org/10.1016/j.freeradbiomed.2018.05.075.

Reid ME, Duffield-Lillico AJ, Garland L, Turnbull BW, Clark LC, Marshall JR. Selenium supplementation and cancer incidence: An update of the nutritional prevention of cancer trial. Cancer epidemiol biomark prev. 2002; 11(11):1285-91.

Whanger PD. Selenium interactions with carcinogens. Fundam Appl Toxicol. 1983; 3(5):424-30.

Avery JC, Hoffmann PR. Selenium, Selenoproteins, and Immunity. Nutrients. 2018; 10(9):E1203.

Vance TM, Su J, Fontham ET, Koo SI, Chun OK. Dietary antioxidants and prostate cancer: a review. Nutr Cancer. 2013; 65(6):793-801.

Pollard M, Luckert PH. Autocthonous prostate adenocarcinomas in Lobund-Wistar rats: a model system. Prostate. 1987; 11:219-27.

Tolosa EMC, Rodrigues CJ, Behmer AO, Freitas Neto A. Manual de práticas para histologia normal e patológica. 1ª ed. São Paulo: Manole; 2003.

Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: Synthesis, identity, and their role in human health. Antioxid Redox Signal. 2007; 9:775–806.

Hurst R, Hooper L, Norat T, Lau R, Aune D, Greenwood DC, et al. Selenium and prostate cancer: systematic review and meta-analysis. Am J Clin Nutr. 2012; 96(1):111-22.

Hayashi N, Sugimura Y, Kawamura J, Donjacour AA, Cunha GR. Morphological and functional heterogeneity in the rat prostatic gland. Biol Reprod. 1991; 45(2):308-21.

Tindall DJ, Rittmaster RS. The rationale for inhibition 5alpha-reductase isoenzymes in the prevention and treatment of prostate cancer. J Urol. 2008; 179(4):1235–42.

Carson C, Rittmaster RS. The role of dihydrotestosterone in benign prostatic hyperplasia. Urology. 2003; 61(4 Suppl 1):2-7.

Galbraith SM, Duchesne GM. Androgens and prostate cancer: Biology, pathology and hormonal therapy. Eur j cancer. 2007; 33(4):545-54.

Ørsted DD, Bojesen SE. The link between benign prostatic hyperplasia and prostate cancer. Nat Rev Urol. 2013; 10(1):49-54.

Marcelli M, Cunningham GR. Hormonal signaling in prostatic hyperplasia and neoplasia. J Clin Endocrinol Metab. 1999; 84(10):3463-8.




Como Citar

de Oliveira, S. M., Silva, L. dos S., Ledesma, R. H. C., & da Silva, R. G. (2018). Histological analysis of rat prostate under exogenous testosterone and low dose of oral selenium administration/ Histología de la próstata de ratón influenciada por testosterona y la dosis supra-nutricional de selenio/ Histologia da próstata de rato. Journal Health NPEPS, 3(2), 380–391. Recuperado de https://periodicos.unemat.br/index.php/jhnpeps/article/view/3131



Artigo Original/ Original Article/ Artículo Originale